Can-Fite Biopharma Ltd (NYSEMKT: CANF) is preparing to initiate a Phase 3 study with piclidenoson for the treatment of rheumatoid arthritis (RA) in the second quarter 2017. The Phase 3 study, called ACRobat, will investigate piclidenoson as a first line therapy and potential replacement for the current standard of care, methotrexate (MTX), in newly diagnosed…
I picked a good day to meet with Can-Fite Biopharma (CANF) because that morning the company announced IRB approval from Hadassah Medical Center and Rabin Medical Center, two leading medical institutions in Israel, to commence patient enrollment in a Phase 2 study of namodenoson (formerly CF102) in the treatment of non-alcoholic fatty liver disease (NAFLD), the precursor…
Can-Fite BioPharma Ltd. (NYSEMKT: CANF) announced on November 1, 2016, that the company reached an agreement with the European Medicines Agency (EMA) on the final design of a global pivotal Phase 3 trial for its lead drug candidate, piclidenoson (formerly CF101), in the treatment of psoriasis. Can-Fite intends to initiate the Phase 3 trial in the…
Last week, Allergan plc (AGN) acquired two companies on the same day, both in an effort to strengthen its focus on NASH. Allergan spent $615 million to acquire Tobira Therapeutics, Inc. (TBRA) and $50 million to acquire privately-held Akarna Therapeutics. The acquisition of Tobira gives Allergan cenicriviroc, an oral Phase 3 ready potent inhibitor of the…
On August 26, 2016, Can-Fite BioPharma, Ltd (CANF) provided a financial update for the six month period ending June 30, 2016. The company also provided an update on its pipeline, which I believe remains meaningfully undervalued. Can-Fite’s market capitalization today is a measly $33 million, and roughly one-third of that is cash. Below is a…
CanFite Biopharma Ltd. (CANF) is currently conducting a Phase 2 clinical study with CF102 for the treatment of hepatocellular carcinoma (HCC). The focus of the study is to test CF102, a selective A3 adenosine receptor (A3AR) agonist, as a second-line treatment of advanced HCC in subjects with Child-Pugh B cirrhosis. The 78-patient trial is currently…
Last week, Gilead Sciences entered into a global partnership for the development and commercialization of filgotinib, a JAK1-selective inhibitor for inflammatory conditions, with Galapagos NV. Galapagos will receive an upfront payment of $725 million consisting of a cash license fee of $300 million and a $425 million equity investment. In addition, Galapagos is eligible for payments up to $1.35…